Sanne Bajwa – ten Broeke

Local Project Coordination

Dr. Sanne Bajwa – ten Broeke 

My PhD research was aimed at delineating the phenotype associated with pathogenic variants in PMS2, both epidemiologically as well as molecularly. In this work we showed that PMS2 carriers are a distinct entity among Lynch syndrome patients with relatively low cancer risks and gene-specific molecular hallmarks of CRC. I am currently finishing my training as a clinical geneticist and combining this with working as projectleader of LYNCH-GPS. In this project we study the early stages of colorectal cancer formation in Lynch syndrome patients, with the aim elucidating differences in tumorigenesis between the different mismatch repair genes. I am also actively involved in the scientific community as y-EHTG board member of the European Hereditary Tumor Group.

Sanne W Bajwa-Ten Broeke, Alexej Ballhausen, Aysel Ahadova, Manon Suerink, Lena Bohaumilitzky, Florian Seidler, Hans Morreau, Tom van Wezel, Julia Krzykalla, Axel Benner, Noel F de Miranda, Magnus von Knebel Doeberitz, Maartje Nielsen, Matthias Kloor. The coding microsatellite mutation profile of PMS2-deficient colorectal cancer. Exp Mol Pathol. 2021 Jul 22;122:104668. doi: 10.1016/j.yexmp.2021.104668.

Ahadova A., Seppälä TT, Engel C, Gallon R, Burn J, Holinski-Feder E, Steinke-Lange V, Möslein G, Nielsen M, ten Broeke S, Laghi L, Dominguez-Valentin M, Capella G, Macrae F, Hüneburg R, Nattermann R, Hoffmeister M, Brenner H, Bläker H, von Knebel Doeberitz M, Sampson JR, Vasen H, Mecklin JP, Møller P, Kloor M. The “unnatural” history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance. Int J Cancer. 2020 Jul 19. doi: 10.1002/ijc.33224.

Ten Broeke SW, van der Klift HM, Tops CMJ, Aretz S, Bernstein I, Buchanan DD, de la Chapelle A, Capella G, Clendenning M, Engel C, Gallinger S, Gomez Garcia E, Figueiredo JC, R Haile, Hampel HL, Hopper JL, Hoogerbrugge N, von Knebel Doeberitz M, Le Marchand L, Letteboer TGW, Jenkins MA, Lindblom A, Lindor NM, Mensenkamp AR, Møller P, Newcomb PA, van Os TAM, Pearlman R, Pineda M, Rahner N, Redeker EJW, Olderode-Berends MJW, Rosty C, Schackert HK, Scott R, Senter L, Spruijt L, Steinke-Lange V, Suerink M, Thibodeau S, Vos YJ, Wagner A, Winship I, Hes FJ, Vasen HFA, Wijnen JT, Nielsen M, and Win AK. Cancer risks for PMS2-associated Lynch syndrome. J Clin Oncol . 2018 Oct 10;36(29):2961-2968. doi: 10.1200/JCO.2018.78.4777.

Ten Broeke SW, van Bavel TC, Jansen AML, Gómez-García E, Hes FJ, van Hest LP, Letteboer TGW, Olderode-Berends MJW, Ruano D, Spruijt L, Suerink M, Tops CM, van Eijk R, Morreau H, van Wezel T, Nielsen M. Molecular Background of Colorectal Tumors From Patients with Lynch Syndrome Associated With Germline Variants in PMS2. Gastroenterology. 2018 Sep;155(3):844-851. doi: 10.1053/j.gastro.2018.05.020.

International Mismatch Repair Consortium. Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study. Lancet Oncology. 2021 July. Lancet Oncol 2021 Jul;22(7):1014-1022. doi: 10.1016/S1470-2045(21)00189-3.

Ballhausen A, Przybilla MJ, Jendrusch J, Haupt S, Pfaffendorf E, Seidler F, Witt J, Hernandez Sanchez A, Unrban K, Draxlbauer M, Krausert S, Ahadova A, Kalteis MS, Pfudere PL, Heid D, Stichel D, Gebert J, Bonsack M, Schott S, Bläker H, Seppälä T, Mecklin JP, Ten Broeke S, Nielsen M, Heuveline V, Krzykalla J, Benner A, Riemer AB, von Knebel Doeberitz M, Kloor M. The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution. Nat Commun. 2020 Sep 21;11(1):4740.
doi: 10.1038/s41467-020-18514-5