Team Heidelberg


Our group has pioneered research on the immune biology of Lynch syndrome-associated microsatellite-unstable (MSI) cancers. We started studying MSI cancer evolution more than 20 years ago and described the major Darwinian selection principles in tumors and characterized possible immune evasion mechanisms. Our most recent research demonstrated the decisive role of the immune system in shaping tumor evolution, pointing particularly at the importance of individual’s HLA type for tumor immunoediting. Using this knowledge, we together with our collaboration partners now aim at linking individual’s HLA type to Lynch syndrome-associated cancer risk and tumor characteristics.

J Clin Med. 2020 Jun 4;9(6):1741. Implications of Hereditary Origin on the Immune Phenotype of Mismatch Repair-Deficient Cancers: Systematic Literature Review.

