Team Leiden

The Leiden University Medical Center (LUMC; The Netherlands) is member of the European Reference Network (ERN GENTURIS) and is highly involved in research focusing on germline variants of DNA repair genes and their consequences for carcinogenesis. Our current research focuses on exploring the molecular and immune profile of colorectal carcinomas from patients with Lynch syndrome, aiming to better understand the underlying mechanisms of cancer development in Lynch syndrome patients.

Maartje Nielsen (Local Project Coordinator)

Noah Helderman (PhD Student)

Tom van Wezel (Senior Scientist)

Hans Morreau (Senior Scientist/Pathologist)

Carli M. Tops (Senior Scientist)

1. Helderman NC, van der Werf-‘t Lam AS, group MSHt, Morreau H, Boot A, van Wezel T, Nielsen M. Molecular profile of MSH6-associated colorectal carcinomas shows distinct features from other Lynch syndrome-associated colorectal carcinomas. Gastroenterology. 2023.

2. Helderman NC, Terlouw D, Bonjoch L, Golubicki M, Antelo M, Morreau H, van Wezel T, Castellví-Bel S, Goldberg Y, Nielsen M, Molecular functions of MCM8 and MCM9 and their associated pathologies, iScience, 2023 May 26;6:106737. doi: 10.1016/j.isci.2023.106737.

3. Helderman NC, Bajwa-Ten Broeke SW, Morreau H, Suerink M, Terlouw D, van der Werf TLAS, van Wezel T, Nielsen M. The diverse molecular profiles of lynch syndrome-associated colorectal cancers are (highly) dependent on underlying germline mismatch repair mutations. Crit Rev Oncol Hematol. 2021;163:103338.

4. Helderman NC, Elsayed FA, van Wezel T, Terlouw D, Langers AMJ, van Egmond D, Kilinc G, Hristova H, Farina Sarasqueta A, Morreau H, Nielsen M, Suerink M, collaborators PA-g. Mismatch repair deficiency and MUTYH variants in small intestine-neuroendocrine tumors. Hum Pathol. 2022;125:11-7.

5. Bajwa-Ten Broeke SW, Ballhausen A, Ahadova A, Suerink M, Bohaumilitzky L, Seidler F, Morreau H, van Wezel T, Krzykalla J, Benner A, de Miranda NF, von Knebel Doeberitz M, Nielsen M, Kloor M. The coding microsatellite mutation profile of PMS2-deficient colorectal cancer. Exp Mol Pathol. 2021;122:104668.

6. Ten Broeke SW, van Bavel TC, Jansen AML, Gomez-Garcia E, Hes FJ, van Hest LP, Letteboer TGW, Olderode-Berends MJW, Ruano D, Spruijt L, Suerink M, Tops CM, van Eijk R, Morreau H, van Wezel T, Nielsen M. Molecular Background of Colorectal Tumors From Patients With Lynch Syndrome Associated With Germline Variants in PMS2. Gastroenterology. 2018;155(3):844-51.

7. Ten Broeke SW, van der Klift HM, Tops CMJ, Aretz S, Bernstein I, Buchanan DD, de la Chapelle A, Capella G, Clendenning M, Engel C, Gallinger S, Gomez Garcia E, Figueiredo JC, Haile R, Hampel HL, Hopper JL, Hoogerbrugge N, von Knebel Doeberitz M, Le Marchand L, Letteboer TGW, Jenkins MA, Lindblom A, Lindor NM, Mensenkamp AR, Moller P, Newcomb PA, van Os TAM, Pearlman R, Pineda M, Rahner N, Redeker EJW, Olderode-Berends MJW, Rosty C, Schackert HK, Scott R, Senter L, Spruijt L, Steinke-Lange V, Suerink M, Thibodeau S, Vos YJ, Wagner A, Winship I, Hes FJ, Vasen HFA, Wijnen JT, Nielsen M, Win AK. Cancer Risks for PMS2-Associated Lynch Syndrome. J Clin Oncol. 2018;36(29):2961-8.